Nigeria: Drug resistance data show merits of using tenofovir in first-line ART regimens

Nigeria: Drug resistance data show merits of using tenofovir in first-line ART regimens

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Download as PowerPoint Slide Figure 6. Tetherin function and virus specific antagonism in different primate hosts. A Mechanism of restricted virion release by tetherin; two alternative models are shown for details, see Evans et al.

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There are controversial breakthroughs of many scientists all over the world, the most recent one originating from Prof. Ezeibe, the small size of the molecules of the medicine’s components allows the medication to reach HIV anywhere in the body, and the electrostatic attraction between the negative charges on the surfaces of the medicine’s components and the positive charges on HIV mops out the virus.

Hence, the synergy between the antiviral effects of the medicine as well as the increased population of the body’s lymphocytes is what cures HIV-AIDS. Ezeibe said, according to The Guardian. You do so through the journals for scientists to do a review of it. The publications we made were reviewed and accepted worldwide,” he added. After its success and confirmation, they published it,” he continued. Ezeibe for allegedly not following established procedures before publicizing his findings.

Ezeibe did not show sufficient evidence that he obtained ethical clearance from an appropriate governing body in Nigeria to conduct the study. It will be a great disservice to this vulnerable group of patients for the media to disseminate these claims in absence of sound scientific evidence,” Aliyu said. The conference is scheduled to take place on July 27—28 in Vancouver, Canada.

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Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Upon entry into the target cell, the viral RNA genome is converted reverse transcribed into double-stranded DNA by a virally encoded enzyme, reverse transcriptase , that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase , and host co-factors.

Alternatively, the integrated viral DNA may be transcribed , producing new RNA genomes and viral proteins, using host cell resources, that are packaged and released from the cell as new virus particles that will begin the replication cycle anew. Two types of HIV have been characterized: A matrix composed of the viral protein p17 surrounds the capsid ensuring the integrity of the virion particle.

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The findings from Nigeria reinforce the World Health Organization recommendation that tenofovir may be a better option for first-line regimens because it maintains susceptibility to thymidine analogue NRTIs AZT and d4T in second-line treatment. However, there are limited data comparing drug resistance patterns associated with tenofovir or AZT-based first-line treatment regimens and their effects on responses to second-line regimens in resource-poor settings.

Nigeria has the second highest burden of HIV worldwide. CRFs refer to two viruses of different subtypes meeting in the cell of an infected person so creating a new hybrid virus. HIV drug resistance testing is not available in resource-poor settings. The authors note evidence suggesting that genetic differences among non-B subtypes exposed to ART may contribute to their pattern of drug resistance.

The authors undertook a cross-sectional study performing genotypic sequencing analysis on stored blood samples from patients on non-nucleoside reverse transcriptase inhibitor NNRTI regimens who got targeted viral load testing to confirm treatment failure. Care and treatment protocols followed Nigerian national guidelines.

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Though there is archaeological evidence that societies have been living in Nigeria for more than twenty-five hundred years, the borders of modern Nigeria were not created until the British consolidated their colonial power over the area in The name Nigeria was suggested by British journalist Flora Shaw in the s. She referred to the area as Nigeria, after the Niger River, which dominates much of the country’s landscape. The word niger is Latin for black. More than ethnic tribes call present-day Nigeria home.

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Check and double, and includes a brief biographical notice of every known Loyalist clergyman. On this page we have collected links to web sites that focus on Anglican and Episcopal history, its people, and its buildings. A rich and outstanding site, the source of most AO Church History entries. This illustrated account of an unsuccessful attempt at establishing an Anglican mission on the western coast of Madagascar is by a missionary of the Society for the Propagation of the Gospel.

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How do you get HIV? HIV can be transmitted during unprotected sex; through sharing injecting equipment; from mother-to-baby during pregnancy, birth and breastfeeding; and through contaminated blood transfusions. HIV cannot survive outside the body. It cannot be spread through the air, from touching, toilet seats or shared cutlery. Taking HIV treatment if you are a new or expectant mother, and avoiding shared injecting equipment if you use drugs, will also protect you and those around you from HIV.

Despite what you may have heard, there are only a few ways you can get HIV. Here, we explain the ways you can get it and how to protect yourself from HIV infection. How can you get HIV? HIV lives in the following bodily fluids of an infected person: To get infected, these bodily fluids need to get into your blood through a mucous membrane for example the lining of the vagina, rectum, the opening of the penis, or the mouth , breaks in the skin like cuts , or be injected directly into your bloodstream.

The main ways you can get HIV are: Sharing injecting equipment sharing needles, syringes or other equipment used to prepare and inject drugs with someone who has HIV. Passed from mother-to-baby during pregnancy, childbirth and breastfeeding a mother infected with HIV can pass the virus to her baby via her blood during pregnancy and birth , and through her breast milk when breastfeeding. This risk is extremely small because most countries test blood products for HIV first.

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